Malgré vs. en dépit de

In French, 'malgré' and 'en dépit de' both function as prepositions meaning 'despite' or 'in spite of'. Each phrase allows speakers to express a contradiction between two situations or facts. Here, we will explore their differences with appropriate examples.

Malgré

This word comes from the Old French 'mal gré', meaning 'bad will'. In modern French, it conveys the idea of doing something against the adversities without necessarily emphasizing the difficulty.
Malgré la pluie, nous sommes allés nous promener.
(Despite the rain, we went for a walk.)
Il sourit malgré la douleur.
(He smiles despite the pain.)
Malgré son jeune âge, elle comprend la complexité du problème.
(Despite her young age, she understands the complexity of the problem.)

En dépit de

'En dépit de' has a similar semantic field as 'malgré', but it's often used to give a slightly stronger connotation meaning to do something defiance of other factors. It sometimes implies a greater struggle or resistance.
En dépit de ses échecs répétés, il continue de persévérer.
(In spite of his repeated failures, he continues to persevere.)
Elle a réussi l'examen en dépit de n'avoir pas beaucoup étudié.
(She passed the exam in spite of not having studied much.)
En dépit des critiques, l'artiste a maintenu sa direction créative.
(Despite the criticisms, the artist maintained his creative direction.)

Summary

'Malgré' and 'en dépit de' are interchangeable in many contexts; however, they can differ subtly in emphasis with 'en dépit de' often suggesting a stronger sense of adversity or resistance. The choice between them can be stylistic or based on the slight nuance one wishes to convey.